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Exam Code: ISO37001CLA

Exam Name: ISO 37001:2016 - Certified Lead Auditor

Certification Provider: GAQM

Related Certification: ISO 37001:2016 - Certified Lead Auditor

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A 55-year-old female is receiving chemotherapy for metastatic carcinoma. She threatens to stop her treatment because of severe nausea and vomiting. The oncologist plans to use prochlorperazine to reduce the nausea and vomiting associated with chemotherapeutic agents. What is the mechanism of action of prochlorperazine?
A. Cannabinoids related
B. H2 receptor antagonist
C. Blockage of prostaglandins
D. Blocking dopamine receptors
E. Serotonin 5-HT3 antagonist
Answer: D
B: A variety of drugs have been found to be of some value in the prevention and treatment of vomiting, especially cancer chemotherapy-induced vomiting. With the exception of thioridazine, most of the neuroleptic drugs have antiemetic effects that are mediated by blocking D2 dopaminergic receptors of the chemoreceptor trigger zone of the medulla. Phenothiazines, such as prochlorperazine, were the first drugs shown to be effective antiemetic agents and act by blocking dopamine receptors. They are effective against low to moderately emetogenic chemotherapeutic agents (for example, fluorouracil and doxorubicin). Although increasing the dose improves antiemetic activity, side effects, including hypotension and restlessness, are dose limiting. Other adverse reactions include extrapyramidal symptom and sedation. A: Serotonin 5-HT3 antagonist is incorrect. The specific antagonists of the 5-HT3 receptor, ondansetron and granisetron, selectively block 5-HT3 receptors in the periphery and in the brain (chemoreceptor trigger zone). C:
Cannabinoids related is incorrect. Cannabinoids are marijuana derivatives including dronabinol and nabilone and are effective against moderately emetogenic chemotherapy. However, they are seldom first-line antiemetics because of serious side effects. D: Blockage of prostaglandins is incorrect. Dexamethasone and methylprednisolone used alone are effective against mildly to moderately emetogenic chemotherapy. Their antiemetic mechanism is not known, but it may involve blockade of prostaglandins. E: H2 receptor antagonist is incorrect. Antagonists of histamine H2 receptor block the action of histamine at all H2 receptors; their chief clinical use is as inhibitors of gastric acid secretion.

Which of the following options are correct about the Al/Machine Learning benefits of running on ACK?
(Number of correct answers: 4)
A. Arena tool was initial develop by alibaba cloud and contribued to kubeflow
B. Heterogeneous computing supported
C. All major machine learning frameworks are supported
D. Optimized k8s scheduling dedicated for jobs running on GPU, such as make pods be tight on GPU node, provide shared GPU, GPU isolated, co-scheduling
E. GPU and shared GPU utilization can NOT be monitoring in Prometheus on alibaba cloud
Answer: A,B,C,D,E

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